In an article, author is Ni, Huanzhen, once mentioned the application of 791-28-6, Name is Triphenylphosphine oxide, molecular formula is C18H15OP, molecular weight is 278.2849, MDL number is MFCD00002080, category is chiral-phosphine-ligands. Now introduce a scientific discovery about this category, Safety of Triphenylphosphine oxide.
Highly Enantioselective [3+2] Annulation of 3-Butynoates with beta-Trifluoromethyl Enones Promoted by an Amine-Phosphine Binary Catalytic System
We report a highly enantioselective [3 + 2] annulation between 3-butynoates and beta-trifluoromethyl enones, furnishing trifluoromethylated cyclopentenes with three contiguous stereogenic centers in good yields, high diastereoselectivities, and excellent enantioselectivities. A unique catalytic system consisting of a simple amine and a chiral phosphine was devised, and the synergistic play of Lewis basic amine and phosphine was crucial for alkyne isomerization and subsequent cyclization. The protocol disclosed herein allows facile activation of 3- butynoates in phosphine-mediated asymmetric transformations.
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Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate