Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 18437-78-0, Name is Tris(4-fluorophenyl)phosphine, molecular formula is C18H12F3P, belongs to chiral-phosphine-ligands compound, is a common compound. In a patnet, author is Du, Peng, once mentioned the new application about 18437-78-0, COA of Formula: C18H12F3P.
A Simple Strategy for the Preparation ofP-Chirogenic Trost Ligands with Different Absolute Configurations
P-chirogenic compounds are useful ligands and organocatalysts in asymmetric synthesis. However, the lack of preparative methods and their configurational instability have significantly hampered their development. Herein, we report a simple strategy for the preparation of enantiomerically pureP,C-chirogenic diphosphines. Amidation of the borane adducts ofrac-phosphinobenzoic acids with enantiomerically puretrans-1,2-diaminocyclohexane afforded a 1:2:1 mixture of the diastereomers (C*,C*,R-p,R-p), (C*,C*,R-p,S-p), and (C*,C*,S-p,S-p), which were separated by column chromatography on silica gel. The prepared (C*,C*,R-p,R-p) and (C*,C*,S-p,S-p) stereoisomers were identical to those obtained from the enantiopure phosphines, which were synthesized by a multi-step route using chiral auxiliaries. Hence, this simple, short and convenient route towardsP,C-chirogenic diphosphines obviates the use of chiral auxiliaries and enables the access to diphosphines with differently configuredP-stereocenters.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 18437-78-0. The above is the message from the blog manager. COA of Formula: C18H12F3P.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate