A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1486-28-8, Name is Methyldiphenylphosphine, molecular formula is C13H13P. In an article, author is Huang, Ke-Xin,once mentioned of 1486-28-8, Safety of Methyldiphenylphosphine.
Enantioselective Synthesis of Carbocyclic Nucleosides via Asymmetric [3+2] Annulation of alpha-Purine-Substituted Acrylates with MBH Carbonates
An efficierit route to chiral carbocyclic nucleoside analogues containing a quaternary stereocenter and a C=C double bond has been establishectia a highly enantioselective [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with a-purine-substituted acrylates. With 20 mol % ‘(S)-SITCP as the catalyst,. various chiral carbocydic nucleoside analogues, with a quaternary stereocenter and C=C.double bond were obtained in high yields (up to 92%) with good diastereoselectivities (up to 10:1 dr) and excellent enantioselectivities (up to 96% ee). Furthermore,the corresponding products were subjected to diverse transformations to afford interesting and potentially useful chiral carbocyclic nucleosides.
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Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate