With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15929-43-8,Bis(4-(trifluoromethyl)phenyl)phosphine oxide,as a common compound, the synthetic route is as follows.
General procedure: A solution of p-QMs (0.20 mmol) and H-phosphorus oxides (0.24 mmol) in dichloromethane (2 mL) were added to cntrifugal tube. Then NaOt-Bu (0.2 mmol) was added to the solution. The reaction mixture was put in ultrasonic cleaner at room temperature for one minute. After reaction, the resulting mixture was diluted with MeOH (2 mL) and concentrated under vacuum to give the crude product which was purified by flash column chromatography (petroleum ether/ethyl acetate 1:1) on silica gel (pH= 6~7, 10% water suspension) to give the product 3., 15929-43-8
15929-43-8 Bis(4-(trifluoromethyl)phenyl)phosphine oxide 12022239, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Article; Jiang, Jun; Kowah, Jamal A. H.; Yuan, Hao; Tetrahedron Letters; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate