Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 51805-45-9, Name is 3,3′,3”-Phosphinetriyltripropanoic acid hydrochloride, molecular formula is C9H16ClO6P. In an article, author is Dai, Qiang,once mentioned of 51805-45-9, HPLC of Formula: C9H16ClO6P.
Construction of P-Chiral Alkenylphosphine Oxides through Highly Chemo-, Regio-, and Enantioselective Hydrophosphinylation of Alkynes
Alkenylphosphine oxides have a wide spectrum of practical applications. However, chemo-, regio-, and enantiocontrolled construction of this structural motif still constitutes a significant synthetic challenge. Here we show that these compounds can be efficiently accessed by using a palladium/Xiao-Phos catalytic system, which leads to the highly regioselective formation of the anti-Markovnikov adducts through addition of a secondary phosphine oxide to an alkyne. Diverse (hetero)aryl and alkyl alkynes, as well as both terminal and internal alkynes can be employed as substrates. The kinetic resolution process makes it possible to produce alkenylphosphine oxide and recovered secondary phosphine oxides with high ee values. Further transformations of these two P-chiral scaffolds confirm the high practicability and application prospect of our synthetic strategies. Initial mechanistic studies strongly suggested that hydropalladation is likely responsible for the conversion process.
Interested yet? Keep reading other articles of 51805-45-9, you can contact me at any time and look forward to more communication. HPLC of Formula: C9H16ClO6P.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate