Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 18437-78-0, Name is Tris(4-fluorophenyl)phosphine, molecular formula is C18H12F3P. In an article, author is Wang, Haiyang,once mentioned of 18437-78-0, Safety of Tris(4-fluorophenyl)phosphine.
Enantioselective gamma-Addition of Pyrazole and Imidazole Heterocycles to Allenoates Catalyzed by Chiral Phosphine
Chiral phosphines were found to catalyze the enantioselective asymmetric gamma-addition of heteroaromatic compounds to allenoates in good yields with high enantiomeric ratios and regioselectivity in the presence of (S)-BINOL. Both pyrazole and imidazole could be employed in this process. The synthetic value of these gamma-addition products was demonstrated by the preparation of biologically relevant molecules and structural scaffolds. Remarkably, the synthetic utility of this strategy was demonstrated through a two-step synthesis of a Janus kinase (JAK) inhibitor.
Interested yet? Keep reading other articles of 18437-78-0, you can contact me at any time and look forward to more communication. Safety of Tris(4-fluorophenyl)phosphine.
Reference:
Phosphine ligand,
,Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate