An Enantioselective Total Synthesis of (-)-Isoschizogamine was written by Xu, Zhengren;Bao, Xu;Wang, Qian;Zhu, Jieping. And the article was included in Angewandte Chemie, International Edition in 2015.Product Details of 1006708-91-3 This article mentions the following:
A concise enantioselective total synthesis of (-)-isoschizogamine, a complex bridged polycyclic monoterpene indole alkaloid, was accomplished. N-Alkylation of an enantio-enriched imine with an alkyl iodide afforded an iminium salt, which, upon heating by microwave irradiation in the presence of pivalic acid, was converted into the hexacyclic structure of natural product by a complex but ordered domino sequence. The one-pot process leading to the formation of one C-C bond and three C-N bonds created three rings and three contiguous stereogenic centers with complete control of both the relative and absolute stereochem. In the experiment, the researchers used many compounds, for example, (R)-2-(2-(Bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole (cas: 1006708-91-3Product Details of 1006708-91-3).
(R)-2-(2-(Bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole (cas: 1006708-91-3) belongs to chiral phosphine ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge. Asymmetric catalytic performance is determined not only by the metal center but also by the chiral ligand selected.Product Details of 1006708-91-3
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis