Bifunctional ferrocene-based squaramide-phosphine as an organocatalyst for highly enantioselective intramolecular Morita-Baylis-Hillman reaction was written by Zhang, Xiaorui;Ma, Pengfei;Zhang, Dongxu;Lei, Yang;Zhang, Shengyong;Jiang, Ru;Chen, Weiping. And the article was included in Organic & Biomolecular Chemistry in 2014.Electric Literature of C26H28FeNP This article mentions the following:
This work demonstrates that, in accord with metal catalysis, ferrocene could be an excellent scaffold for organocatalysts. The simple and easily accessible bifunctional ferrocene-based squaramide-phosphine shows high enantioselectivity in the intramol. Morita-Baylis-Hillman reaction of 7-aryl-7-oxo-5-heptenals, giving a variety of 2-aroyl-2-cyclohexenols in up to 96% ee. In the experiment, the researchers used many compounds, for example, (R)-N,N-Dimethyl-1-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine (cas: 55700-44-2Electric Literature of C26H28FeNP).
(R)-N,N-Dimethyl-1-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine (cas: 55700-44-2) belongs to chiral phosphine ligands. Generally, the efficiency of nucleophilic phosphine catalysis often depends on the nature of the tertiary phosphine. Over the last decade, however, and especially since 2005, considerable progress has been made in asymmetric phosphine catalysis.Electric Literature of C26H28FeNP
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis