Copper(I) Alkoxide-Catalyzed Alkynylation of Trifluoromethyl Ketones was written by Motoki, Rie;Kanai, Motomu;Shibasaki, Masakatsu. And the article was included in Organic Letters in 2007.Related Products of 352655-61-9 This article mentions the following:
A general method for direct alkynylation of trifluoromethyl ketones to afford the corresponding tertiary propargyl alcs., e.g., I, was developed using CuOtBu-xantphos or phenanthroline complexes as catalysts. The ligands significantly enhanced the catalyst activity. In addition, KOTf, generated in the catalyst preparation step, exhibited some acceleration effects. A preliminary extension to a catalytic enantioselective CF3-substituted tertiary propargyl alc. synthesis (up to 52% ee) is also described. In the experiment, the researchers used many compounds, for example, (R)-(-)-2,2′-Bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-6,6′-dimethoxy-1,1′-biphenyl (cas: 352655-61-9Related Products of 352655-61-9).
(R)-(-)-2,2′-Bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-6,6′-dimethoxy-1,1′-biphenyl (cas: 352655-61-9) belongs to chiral phosphine ligands. Many phosphine-catalyzed reactions have been developed for the syntheses of various biologically important acyclic and cyclic molecules. Asymmetric variants of these reactions have evolved relatively slowly. Over the last decade, however, and especially since 2005, considerable progress has been made in asymmetric phosphine catalysis.Related Products of 352655-61-9
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis