Enantioselective α-Allylation of Anilines Enabled by a Combined Palladium and Photoredox Catalytic System was written by Zhang, Hong-Hao;Zhao, Jia-Jia;Yu, Shouyun. And the article was included in ACS Catalysis in 2020.HPLC of Formula: 352655-61-9 This article mentions the following:
An enantioselective and branch-regioselective α-allylation of N-Me anilines with allylic acetates under dual palladium/photoredox catalysis was described. Readily available N-Me anilines were used as formal ”hard” alkyl nucleophiles without preactivation. Acetic acid was the only side product, which led to a high atom economy of this reaction. This protocol showed good functional group tolerance and broad scope. A range of chiral homoallylic amines I [R = Me, i-Pr, Ph, etc.; Ar1 = Ph, 4-MeOC6H4, 4-NHAcC6H4, etc.; Ar2 = Ph, 3-MeC6H4, 4-ClC6H4, etc.] were prepared in moderate to good yields (up to 76%) and excellent regioselectivities (B:L > 95:5 in all cases) and enantioselectivities (up to 96% ee) under mild reaction conditions. In the experiment, the researchers used many compounds, for example, (R)-(-)-2,2′-Bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-6,6′-dimethoxy-1,1′-biphenyl (cas: 352655-61-9HPLC of Formula: 352655-61-9).
(R)-(-)-2,2′-Bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-6,6′-dimethoxy-1,1′-biphenyl (cas: 352655-61-9) belongs to chiral phosphine ligands. Phosphine-catalyzed asymmetric reactions are now powerful and versatile tools for the construction of C–C, C–N, C–O, and C–S bonds and for the syntheses of functionalized carbocycles and heterocycles. Chiral phosphine catalysts: Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates.HPLC of Formula: 352655-61-9
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis