Enantioselective Synthesis of 3,3-Disubstituted Oxindoles through Pd-Catalyzed Cyanoamidation was written by Yasui, Yoshizumi;Kamisaki, Haruhi;Takemoto, Yoshiji. And the article was included in Organic Letters in 2008.Quality Control of (S)-(2′-Methoxy-[1,1′-binaphthalen]-2-yl)diphenylphosphine This article mentions the following:
The first enantioselective intramol. cyanoamidation of olefins provides quick access to a variety of 3,3-disubstituted oxindoles. The combination of Pd(dba)2, optically active phosphoramidite I, and N,N-dimethylpropylene urea (DMPU) in decalin were found to be the best conditions. In the experiment, the researchers used many compounds, for example, (S)-(2′-Methoxy-[1,1′-binaphthalen]-2-yl)diphenylphosphine (cas: 134484-36-9Quality Control of (S)-(2′-Methoxy-[1,1′-binaphthalen]-2-yl)diphenylphosphine).
(S)-(2′-Methoxy-[1,1′-binaphthalen]-2-yl)diphenylphosphine (cas: 134484-36-9) belongs to chiral phosphine ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge. Indeed, very little research on chiral tertiary phosphine-catalyzed asymmetric reactions occurred prior to the year 2000.Quality Control of (S)-(2′-Methoxy-[1,1′-binaphthalen]-2-yl)diphenylphosphine
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis