Iridium Catalysts with f-Amphox Ligands: Asymmetric Hydrogenation of Simple Ketones was written by Wu, Weilong;Liu, Shaodong;Duan, Meng;Tan, Xuefeng;Chen, Caiyou;Xie, Yun;Lan, Yu;Dong, Xiu-Qin;Zhang, Xumu. And the article was included in Organic Letters in 2016.COA of Formula: C26H28FeNP This article mentions the following:
A series of modular and rich electronic tridentate ferrocene aminophosphoxazoline ligands (f-amphox) have been successfully developed and used in iridium-catalytic asym. hydrogenation of simple ketones to afford corresponding enantiomerically enriched alcs. under mild conditions with superb activities and excellent enantioselectivities (up to 1,000,000 TON, almost all products up to >99% ee, full conversion). The resulting chiral alcs. and their derivatives are important intermediates in pharmaceuticals. In the experiment, the researchers used many compounds, for example, (R)-N,N-Dimethyl-1-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine (cas: 55700-44-2COA of Formula: C26H28FeNP).
(R)-N,N-Dimethyl-1-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine (cas: 55700-44-2) belongs to chiral phosphine ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge. Chiral phosphine catalysts: Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates.COA of Formula: C26H28FeNP
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis