Exercising Regiocontrol in Palladium-Catalyzed Asymmetric Prenylations and Geranylation: Unifying Strategy toward Flustramines A and B was written by Trost, Barry M.;Malhotra, Sushant;Chan, Walter H.. And the article was included in Journal of the American Chemical Society in 2011.Recommanded Product: 174810-09-4 This article mentions the following:
Pd-catalyzed asym. prenylation of oxindoles to afford selectively either the prenyl or reverse-prenyl products, e.g. I and II, has been demonstrated. Control of the regioselectivity in this transformation is governed by the choice of ligand, solvent, and halide additive. The resulting prenylated and reverse-prenylated products were transformed into ent-flustramides and ent-flustramines A and B. Addnl., control of the regio- and diastereoselectivity was obtained using π-geranylpalladium complexes. In the experiment, the researchers used many compounds, for example, N,N’-((1R,2R)-Cyclohexane-1,2-diyl)bis(2-(diphenylphosphino)-1-naphthamide) (cas: 174810-09-4Recommanded Product: 174810-09-4).
N,N’-((1R,2R)-Cyclohexane-1,2-diyl)bis(2-(diphenylphosphino)-1-naphthamide) (cas: 174810-09-4) belongs to chiral phosphine ligands. Although many reactions require more nucleophilic trialkylphosphines as catalysts, only a few chiral trialkylphosphines are available. Effective chiral catalysts for nucleophilic phosphine catalysis are scarce, seriously limiting the development of asymmetric variants. Recommanded Product: 174810-09-4
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis