Enantioselective and Regio-divergent Addition of Purines to Terminal Allenes: Synthesis of Abacavir was written by Thieme, Niels;Breit, Bernhard. And the article was included in Angewandte Chemie, International Edition in 2017.Formula: C42H56FeO2P2 This article mentions the following:
The rhodium-catalyzed atom-economic asym. N-selective intermol. addition of purine derivatives to terminal allenes is reported. Branched allylic purines were obtained in high yields, regioselectivity and outstanding enantioselectivity utilizing a Rh/Josiphos catalyst. Conversely, linear selective allylation of purines could be realized in good to excellent regio- and E/Z-selectivity with a Pd/dppf catalyst system. Furthermore, the new methodol. was applied to a straightforward asym. synthesis of carbocyclic nucleoside abacavir. In the experiment, the researchers used many compounds, for example, (1R)-1-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2-[(1R)-1-(dicyclohexylphosphino)ethyl]ferrocene (cas: 360048-63-1Formula: C42H56FeO2P2).
(1R)-1-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2-[(1R)-1-(dicyclohexylphosphino)ethyl]ferrocene (cas: 360048-63-1) belongs to chiral phosphine ligands. Phosphine-catalyzed asymmetric reactions are now powerful and versatile tools for the construction of C–C, C–N, C–O, and C–S bonds and for the syntheses of functionalized carbocycles and heterocycles. Chiral ligands coordinate to metal centers to create an asymmetric environment around the reaction centers, which eventually affects enantioselectivity and reaction rate.Formula: C42H56FeO2P2
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis