Defined rhodium-MandyPhos pre-catalyst systems was written by Nass, Andreas Rivas;Doppiu, Angelino;Karch, Ralf;Schuster, Andreas;Stephen, A.;Hashmi, K.. And the article was included in Chimica Oggi in 2009.Reference of 174467-31-3 This article mentions the following:
Investigations of Ru- and Rh-based chiral hydrogenation reactions using the ligands MandyPhos and TaniaPhos are up to now based on in situ protocols. The purpose of this and prior work was the clear and detailed structural description of isolated rhodium and ruthenium pre-catalysts with these ligands in order to develop defined ready to use catalytic systems for asym. synthesis. In the case of ruthenium it was found that it is possible to isolate and identify well-defined pre-catalyst systems only by establishing new protocols for complex synthesis. Driven by those experiences, the coordination behavior of MandyPhos with rhodium was investigated and a similar picture emerged. This study provides new synthetic routes to stable rhodium complexes with MandyPhos ligands and norbornadiene or cyclooctadiene ancillary ligands. In the experiment, the researchers used many compounds, for example, (R,R)-2,2′-Bis[(R)-(N,N-dimethylamino)(phenyl)methyl]-1,1′-bis(diphenylphosphino)ferrocene (cas: 174467-31-3Reference of 174467-31-3).
(R,R)-2,2′-Bis[(R)-(N,N-dimethylamino)(phenyl)methyl]-1,1′-bis(diphenylphosphino)ferrocene (cas: 174467-31-3) belongs to chiral phosphine ligands. The synthesis of novel trialkylphosphines can be quite difficult, thereby limiting the scope of their chiral variants. Chiral ligands coordinate to metal centers to create an asymmetric environment around the reaction centers, which eventually affects enantioselectivity and reaction rate.Reference of 174467-31-3
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis