Catalytic enantioselective addition of phenylboronic acid and phenylboroxine to N-tosylimines: PdII and RhI catalysis was written by Marques, Carolina S.;Burke, Anthony J.. And the article was included in European Journal of Organic Chemistry in 2010.COA of Formula: C52H44N2O2P2 This article mentions the following:
This is the first account of a successful, PdII-catalyzed enantioselective addition of phenylboronic acid to electron-deficient N-tosylarylimines by using chiral diphosphane ligands. A number of com. diphosphane ligands were screened. Despite moderate to good yields, ee values of 99% could be achieved with MeDuPhos. Novel RhI catalysts were also screened, and ee values as high as 74% could be obtained. In the experiment, the researchers used many compounds, for example, N,N’-((1R,2R)-Cyclohexane-1,2-diyl)bis(2-(diphenylphosphino)-1-naphthamide) (cas: 174810-09-4COA of Formula: C52H44N2O2P2).
N,N’-((1R,2R)-Cyclohexane-1,2-diyl)bis(2-(diphenylphosphino)-1-naphthamide) (cas: 174810-09-4) belongs to chiral phosphine ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge. Chiral phosphine catalysts: Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates.COA of Formula: C52H44N2O2P2
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis