Asymmetric hydrogenation of quinolines activated by Bronsted acids was written by Wang, Duo-Sheng;Zhou, Yong-Gui. And the article was included in Tetrahedron Letters in 2010.Application In Synthesis of (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine) This article mentions the following:
Enantioselective hydrogenation of quinolines and quinoxalines catalyzed by iridium/diphosphine complex with a catalytic amount of Bronsted acid as an activator was developed. In the presence of piperidine·trifluoromethanesulfonic acid as the activator, full conversions and up to 92% ee were obtained. In the experiment, the researchers used many compounds, for example, (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine) (cas: 37002-48-5Application In Synthesis of (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine)).
(((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine) (cas: 37002-48-5) belongs to chiral phosphine ligands. The synthesis of novel trialkylphosphines can be quite difficult, thereby limiting the scope of their chiral variants. Effective chiral catalysts for nucleophilic phosphine catalysis are scarce, seriously limiting the development of asymmetric variants. Application In Synthesis of (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine)
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis