Palladium-catalyzed DYKAT of vinyl epoxides: Enantioselective total synthesis and assignment of the configuration of (+)-broussonetine G was written by Trost, Barry M.;Horne, Daniel B.;Woltering, Michael J.. And the article was included in Angewandte Chemie, International Edition in 2003.HPLC of Formula: 174810-09-4 This article mentions the following:
A potential general approach to potent N-heterocyclic glycosidase inhibitors is illustrated by the first total synthesis of (+)-broussonetine G. The key transformation of the synthesis relies on two successive palladium-catalyzed asym. allylic alkylations of butadiene monoxide with a nitrogen nucleophile to construct the pyrrolidine core. In the experiment, the researchers used many compounds, for example, N,N’-((1R,2R)-Cyclohexane-1,2-diyl)bis(2-(diphenylphosphino)-1-naphthamide) (cas: 174810-09-4HPLC of Formula: 174810-09-4).
N,N’-((1R,2R)-Cyclohexane-1,2-diyl)bis(2-(diphenylphosphino)-1-naphthamide) (cas: 174810-09-4) belongs to chiral phosphine ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge. Chiral phosphine catalysts: Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates.HPLC of Formula: 174810-09-4
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis