Efficient synthesis of chiral 1,3-diols and of 1-substituted-propan-1-ols through asymmetric hydrogenation was written by Touati, Ridha;Ben Hassine, Bechir. And the article was included in Journal de la Societe Chimique de Tunisie in 2008.Application of 133545-16-1 This article mentions the following:
Asym. hydrogenations of an achiral β-keto ester using a chiral diphosphine-ruthenium catalyst to set the hydroxyl function in a stereo controlled manner were used in key-step towards the total synthesis of both enantiomers of secondary alcs. with excellent enantioselectivity (>99% ee) and high yields. In the experiment, the researchers used many compounds, for example, (R)-(6,6′-Dimethoxy-[1,1′-biphenyl]-2,2′-diyl)bis(diphenylphosphine) (cas: 133545-16-1Application of 133545-16-1).
(R)-(6,6′-Dimethoxy-[1,1′-biphenyl]-2,2′-diyl)bis(diphenylphosphine) (cas: 133545-16-1) belongs to chiral phosphine ligands. Many phosphine-catalyzed reactions have been developed for the syntheses of various biologically important acyclic and cyclic molecules. Asymmetric variants of these reactions have evolved relatively slowly. Effective chiral catalysts for nucleophilic phosphine catalysis are scarce, seriously limiting the development of asymmetric variants. Application of 133545-16-1
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis