Low-pressure Cobalt-Catalyzed Enantioselective Hydrovinylation of Vinylarenes was written by Movahhed, Sohajl;Westphal, Julia;Dindaroglu, Mehmet;Falk, Anna;Schmalz, Hans-Guenther. And the article was included in Chemistry – A European Journal in 2016.Formula: C24H20NO3P This article mentions the following:
An efficient and practical protocol for the enantioselective cobalt-catalyzed hydrovinylation of vinylarenes with ethylene at low (1.2 bar) pressure was developed. As precatalysts, stable [L2CoCl2] complexes were employed that were activated in situ with Et2AlCl. A modular chiral TADDOL-derived phosphine-phosphite ligand was identified and that allowed the conversion of a broad spectrum of substrates including heterocyclic vinylarenes and vinylferrocene to smoothly afford the branched products with up to 99 % ee and virtually complete regioselectivity. Even polar functional groups such as OH, NH2, CN, and CO2R were tolerated. In the experiment, the researchers used many compounds, for example, (S)-4-(Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl)morpholine (cas: 185449-81-4Formula: C24H20NO3P).
(S)-4-(Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl)morpholine (cas: 185449-81-4) belongs to chiral phosphine ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge. Most of these phosphines are acyclic, usually possess low nucleophilic activity, and generally display poor enantioselectivities for phosphine organocatalysis. Formula: C24H20NO3P
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis