Highly enantioselective spirocyclization of 1,6-enynes catalyzed by cationic skewphos rhodium(I) complex was written by Mikami, Koichi;Yusa, Yukinori;Hatano, Manabu;Wakabayashi, Kazuki;Aikawa, Kohsuke. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2004.Computed Properties of C29H30P2 This article mentions the following:
A cationic rhodium(I) complex having a skewphos ligand was a highly enantioselective catalyst for asym. carbocyclization of 1,6-enynes. 1,6-Enynes, e.g., I, underwent spirocyclization to give spiro-cycles, e.g., II, with good control of the newly formed quaternary stereogenic centers of the spiro-rings. In the experiment, the researchers used many compounds, for example, (2S,4S)-Pentane-2,4-diylbis(diphenylphosphine) (cas: 77876-39-2Computed Properties of C29H30P2).
(2S,4S)-Pentane-2,4-diylbis(diphenylphosphine) (cas: 77876-39-2) belongs to chiral phosphine ligands. Phosphine-catalyzed asymmetric reactions are now powerful and versatile tools for the construction of C–C, C–N, C–O, and C–S bonds and for the syntheses of functionalized carbocycles and heterocycles. Trivalent phosphorus compounds called phosphines have a tetrahedral electron-group geometry which makes them structurally analogous to amines.Computed Properties of C29H30P2
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis