Dynamic kinetic asymmetric allylation of hydrazines and hydroxylamines was written by Mangion, Ian;Strotman, Neil;Drahl, Michael;Imbriglio, Jason;Guidry, Erin. And the article was included in Organic Letters in 2009.SDS of cas: 174810-09-4 This article mentions the following:
Hydrazines and hydroxylamines have been found to be excellent nucleophiles for the palladium-catalyzed dynamic asym. allylic amination of vinyl epoxide, with good yields and enantioselectivities of up to 97% ee. This method is applicable to acyclic and heterocyclic amines and was applied toward a five-step synthesis of (R)-piperazic acid. In the experiment, the researchers used many compounds, for example, N,N’-((1R,2R)-Cyclohexane-1,2-diyl)bis(2-(diphenylphosphino)-1-naphthamide) (cas: 174810-09-4SDS of cas: 174810-09-4).
N,N’-((1R,2R)-Cyclohexane-1,2-diyl)bis(2-(diphenylphosphino)-1-naphthamide) (cas: 174810-09-4) belongs to chiral phosphine ligands. Phosphine-catalyzed asymmetric reactions are now powerful and versatile tools for the construction of C–C, C–N, C–O, and C–S bonds and for the syntheses of functionalized carbocycles and heterocycles. Chiral phosphine catalysts: Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates.SDS of cas: 174810-09-4
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis