Palladium-Catalyzed Enantioselective C-H Arylation for the Synthesis of P-Stereogenic Compounds was written by Lin, Zi-Qi;Wang, Wei-Zhen;Yan, Shao-Bai;Duan, Wei-Liang. And the article was included in Angewandte Chemie, International Edition in 2015.Reference of 134484-36-9 This article mentions the following:
A palladium-catalyzed enantioselective C-H arylation of N-(o-bromoaryl)-diarylphosphinic amides is described for the synthesis of phosphorus compounds bearing a P-stereogenic center. The method provides good enantioselectivities and high yields. The products were readily transformed into P-chiral biphenyl monophosphine ligands. In the experiment, the researchers used many compounds, for example, (S)-(2′-Methoxy-[1,1′-binaphthalen]-2-yl)diphenylphosphine (cas: 134484-36-9Reference of 134484-36-9).
(S)-(2′-Methoxy-[1,1′-binaphthalen]-2-yl)diphenylphosphine (cas: 134484-36-9) belongs to chiral phosphine ligands. Although many reactions require more nucleophilic trialkylphosphines as catalysts, only a few chiral trialkylphosphines are available. Chiral ligands coordinate to metal centers to create an asymmetric environment around the reaction centers, which eventually affects enantioselectivity and reaction rate.Reference of 134484-36-9
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis