Asymmetric synthesis catalyzed by chiral ferrocenylphosphine-transition metal complexes. I. Preparation of chiral ferrocenylphosphines was written by Hayashi, Tamio;Mise, Takaya;Fukushima, Motoo;Kagotani, Masahiro;Nagashima, Nobuo;Hamada, Yuji;Matsumoto, Akira;Kawakami, Sota;Konishi, Mitsuo. And the article was included in Bulletin of the Chemical Society of Japan in 1980.Computed Properties of C26H28FeNP This article mentions the following:
As chiral ligands for transition metal complex catalyzed asym. reactions, various kinds of chiral ferrocenylphosphines, which have planar chirality due to 1,2-unsym. substituted ferrocene structure and also have a functional group on the side chain of the ferrocene nucleus, were prepared (S)-N,N-Dimethyl-1-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine, (S)-N,N-dimethyl-1-[(R)-1′,2-bis(diphenylphosphino)ferrocenyl]ethylamine and their dimethylphosphino derivatives were prepared by lithiation of optically resolved N,N-dimethyl-1-ferrocenylethylamine. The 1-(dimethylamino)ethyl group on the ferrocenylphosphines was converted stereospecifically by nucleophilic substitution reactions into 1-methoxy-, 1-hydroxy-, 1-diphenylphosphino-, and several 1-(dialkylamino)ethyl groups. 1-(Diphenylphosphino)-2-(dimethylaminomethyl)ferrocene was optically resolved via its phosphine sulfide dibenzoyltartaric acid salt. The relationship between CD spectra of the chiral ferrocenylphosphines and the configuration of their chirality is discussed. In the experiment, the researchers used many compounds, for example, (R)-N,N-Dimethyl-1-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine (cas: 55700-44-2Computed Properties of C26H28FeNP).
(R)-N,N-Dimethyl-1-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine (cas: 55700-44-2) belongs to chiral phosphine ligands. The synthesis of novel trialkylphosphines can be quite difficult, thereby limiting the scope of their chiral variants. Trivalent phosphorus compounds called phosphines have a tetrahedral electron-group geometry which makes them structurally analogous to amines.Computed Properties of C26H28FeNP
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis