Histidine and deuterium labeled histidine by asymmetric catalytic reduction with gaseous H2 or D2; the role of strong non-coordinating acids was written by Cesarotti, E.;Rimoldi, I.;Zerla, D.;Aldini, G.. And the article was included in Tetrahedron: Asymmetry in 2008.Product Details of 77876-39-2 This article mentions the following:
An efficient and convenient route for the preparation of natural and unnatural histidine by asym. hydrogenation with rhodium-phosphine complexes is described. The reductions were performed in the presence of HBF4 to generate an essential imidazolyl cation. Stereoselective incorporation of D2 in the α,β-positions was obtained by catalytic deuteration in the presence of MeOD. In the experiment, the researchers used many compounds, for example, (2S,4S)-Pentane-2,4-diylbis(diphenylphosphine) (cas: 77876-39-2Product Details of 77876-39-2).
(2S,4S)-Pentane-2,4-diylbis(diphenylphosphine) (cas: 77876-39-2) belongs to chiral phosphine ligands. Phosphine-catalyzed asymmetric reactions are now powerful and versatile tools for the construction of C–C, C–N, C–O, and C–S bonds and for the syntheses of functionalized carbocycles and heterocycles. Asymmetric catalytic performance is determined not only by the metal center but also by the chiral ligand selected.Product Details of 77876-39-2
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis