Asymmetric cross-coupling reactions: enantioselective synthesis of alkenyl sulfides was written by Cardellicchio, Cosimo;Fiandanese, Vito;Naso, Francesco. And the article was included in Gazzetta Chimica Italiana in 1991.COA of Formula: C26H28FeNP This article mentions the following:
An enantioselective synthesis of alkenyl sulfides by cross-coupling reactions between (E)- or (Z)-ArSCH:CHBr (I; Ar = Ph, 2-naphthyl, 2-pyridyl) and Grignard or organozinc reagents, using chiral complexes as catalysts, is described. The process is sensitive to several factors, e.g., the nature of the substrate, the organometallic reagent, the ligand, and the metal complex used as catalyst. Optical purities of up to 57% were achieved. The resulting unsaturated thioethers have been transformed into optically active 1-alkyl-2-phenylethenes or MeCHPhCO2H. A new method for the synthesis of the starting (Z)-I is also reported. In the experiment, the researchers used many compounds, for example, (R)-N,N-Dimethyl-1-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine (cas: 55700-44-2COA of Formula: C26H28FeNP).
(R)-N,N-Dimethyl-1-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine (cas: 55700-44-2) belongs to chiral phosphine ligands. During the past two decades, tertiary phosphine catalysts have been applied extensively in a wide range of carbon–carbon and carbon–heteroatom bond-forming transformations. Chiral ligands coordinate to metal centers to create an asymmetric environment around the reaction centers, which eventually affects enantioselectivity and reaction rate.COA of Formula: C26H28FeNP
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis