Rhodium-Catalyzed Asymmetric Synthesis of Indanones: Development of a New “Axially Chiral” Bisphosphine Ligand was written by Shintani, Ryo;Yashio, Keiji;Nakamura, Tomoaki;Okamoto, Kazuhiro;Shimada, Toyoshi;Hayashi, Tamio. And the article was included in Journal of the American Chemical Society in 2006.Application of 133545-16-1 This article mentions the following:
A rhodium-catalyzed asym. isomerization of racemic α-arylpropargyl alcs. to β-chiral indanones has been developed. High enantioselectivity has been realized by the use of a newly developed axially chiral bisphosphine ligand. This ligand is unique in the sense that its axial chirality is fixed to a single configuration upon complexation to a transition metal due to other chiral axes existing within the same mol. In the experiment, the researchers used many compounds, for example, (R)-(6,6′-Dimethoxy-[1,1′-biphenyl]-2,2′-diyl)bis(diphenylphosphine) (cas: 133545-16-1Application of 133545-16-1).
(R)-(6,6′-Dimethoxy-[1,1′-biphenyl]-2,2′-diyl)bis(diphenylphosphine) (cas: 133545-16-1) belongs to chiral phosphine ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge. Asymmetric catalytic performance is determined not only by the metal center but also by the chiral ligand selected.Application of 133545-16-1
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis