A new practical asymmetric synthesis of C2-symmetrical 1,1′-ferrocenyl diols via CBS-reduction was written by Schwink, Lothar;Knochel, Paul. And the article was included in Tetrahedron Letters in 1996.Name: (R,R)-2,2′-Bis[(R)-(N,N-dimethylamino)(phenyl)methyl]-1,1′-bis(diphenylphosphino)ferrocene This article mentions the following:
Oxazaborolidine-catalyzed borane-reduction of ferrocenyl diketones I [R = Me, i-Pr, pentyl, Ph, (CH2)3CO2Me] provides C2-sym. ferrocenyl diols (R,R)-1 (II) in >98% ee accompanied by small amounts of the meso-diols (R,S)-1. The utility of 1 for the preparation of various potential ligands for asym. catalysis such as III (R = Ph, pentyl) is demonstrated. In the experiment, the researchers used many compounds, for example, (R,R)-2,2′-Bis[(R)-(N,N-dimethylamino)(phenyl)methyl]-1,1′-bis(diphenylphosphino)ferrocene (cas: 174467-31-3Name: (R,R)-2,2′-Bis[(R)-(N,N-dimethylamino)(phenyl)methyl]-1,1′-bis(diphenylphosphino)ferrocene).
(R,R)-2,2′-Bis[(R)-(N,N-dimethylamino)(phenyl)methyl]-1,1′-bis(diphenylphosphino)ferrocene (cas: 174467-31-3) belongs to chiral phosphine ligands. Although many reactions require more nucleophilic trialkylphosphines as catalysts, only a few chiral trialkylphosphines are available. Asymmetric catalytic performance is determined not only by the metal center but also by the chiral ligand selected.Name: (R,R)-2,2′-Bis[(R)-(N,N-dimethylamino)(phenyl)methyl]-1,1′-bis(diphenylphosphino)ferrocene
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis