Schwink, Lothar et al. published their research in Chemistry – A European Journal in 1998 | CAS: 174467-31-3

(R,R)-2,2′-Bis[(R)-(N,N-dimethylamino)(phenyl)methyl]-1,1′-bis(diphenylphosphino)ferrocene (cas: 174467-31-3) belongs to chiral phosphine ligands. During the past two decades, tertiary phosphine catalysts have been applied extensively in a wide range of carbon–carbon and carbon–heteroatom bond-forming transformations. Most of these phosphines are acyclic, usually possess low nucleophilic activity, and generally display poor enantioselectivities for phosphine organocatalysis. Category: chiral-phosphine-ligands

Enantioselective preparation of C2-symmetrical ferrocenyl ligands for asymmetric catalysis was written by Schwink, Lothar;Knochel, Paul. And the article was included in Chemistry – A European Journal in 1998.Category: chiral-phosphine-ligands This article mentions the following:

Corey-Bakshi-Shibata (CBS) reduction of the 1,1′-diacylmetallocenes of Fe and Ru (e.g. 1,1′-(ClCH2CH2CH2C(O))2ferrocene) provides the C2-sym. diols 4 (e.g. (R,R)-1,1′-(MeCH(OH))2ferrocene) and 10, which proved to be useful starting materials for stereo-controlled ligand synthesis. Diols 4 and 10 can be easily converted to a wide range of diamines, diphosphines, and dithioacetates by nucleophilic substitution of the hydroxyl function with full retention of configuration. Also, the aminophosphines 30 (e.g. (αR,α’R)-2,2′-bis(α-(dimethylamino)(phenyl)methyl)-(S,S)-1,1′-bis(diphenylphosphino)ferrocene) and 31 (the Ru analog of the example for 30) become easily accessible. Compounds 30 and 31 were used as ligands complexed to Pd in enantioselective cross-coupling of racemic secondary Grignard reagents with vinyl bromides. A selectivity up to 93% ee could be reached for the 1st time in the preparation of (S)-(E)-1,3-diphenyl-1-butene, which was transformed into the enantiomerically pure chiral building block (2R,4R)-2,4-diphenyl-3-pentanol with a pseudoasym. center in a straightforward, three-step synthesis. In the experiment, the researchers used many compounds, for example, (R,R)-2,2′-Bis[(R)-(N,N-dimethylamino)(phenyl)methyl]-1,1′-bis(diphenylphosphino)ferrocene (cas: 174467-31-3Category: chiral-phosphine-ligands).

(R,R)-2,2′-Bis[(R)-(N,N-dimethylamino)(phenyl)methyl]-1,1′-bis(diphenylphosphino)ferrocene (cas: 174467-31-3) belongs to chiral phosphine ligands. During the past two decades, tertiary phosphine catalysts have been applied extensively in a wide range of carbon–carbon and carbon–heteroatom bond-forming transformations. Most of these phosphines are acyclic, usually possess low nucleophilic activity, and generally display poor enantioselectivities for phosphine organocatalysis. Category: chiral-phosphine-ligands

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis