Solid-phase synthesis of recyclable diphosphine ligands was written by Heutz, Frank J. L.;Samuels, Michiel C.;Kamer, Paul C. J.. And the article was included in Catalysis Science & Technology in 2015.Safety of (2S,4S)-Pentane-2,4-diylbis(diphenylphosphine) This article mentions the following:
An efficient solid-phase synthetic approach towards diphosphine ligands is demonstrated. This modular method offers facile access to this important class of ligands, in quant. yield, providing huge potential for ligand fine-tuning. These supported ligands can be efficiently applied in asym. catalysis. Moreover, the immobilized catalysts can successfully be recycled multiple times addressing several synthetic and work-up challenges in the field of catalytic chem. In the experiment, the researchers used many compounds, for example, (2S,4S)-Pentane-2,4-diylbis(diphenylphosphine) (cas: 77876-39-2Safety of (2S,4S)-Pentane-2,4-diylbis(diphenylphosphine)).
(2S,4S)-Pentane-2,4-diylbis(diphenylphosphine) (cas: 77876-39-2) belongs to chiral phosphine ligands. During the past two decades, tertiary phosphine catalysts have been applied extensively in a wide range of carbon–carbon and carbon–heteroatom bond-forming transformations. Trivalent phosphorus compounds called phosphines have a tetrahedral electron-group geometry which makes them structurally analogous to amines.Safety of (2S,4S)-Pentane-2,4-diylbis(diphenylphosphine)
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis