Palladium-catalyzed intramolecular direct arylation for phosphorus heterocycle synthesis was written by Chen, Yun-Rong;Duan, Wei-Liang. And the article was included in Synthesis in 2014.Synthetic Route of C33H25OP This article mentions the following:
A Pd-catalyzed intramol. direct arylation of bromo-substituted phosphine oxides is reported for the synthesis of P-containing heterocycles with good to excellent yields (78-98 %). E.g., reaction of Ph2P(O)CH2-2-C6H4Br with 10 mol% Pd(OAc)2/10 mol% PPh3 with K2CO3/DMA at 60° gave a 98% yield of 5,6-dihydro-5-phenylphosphanthridine 5-oxide. In the experiment, the researchers used many compounds, for example, (S)-(2′-Methoxy-[1,1′-binaphthalen]-2-yl)diphenylphosphine (cas: 134484-36-9Synthetic Route of C33H25OP).
(S)-(2′-Methoxy-[1,1′-binaphthalen]-2-yl)diphenylphosphine (cas: 134484-36-9) belongs to chiral phosphine ligands. Although many reactions require more nucleophilic trialkylphosphines as catalysts, only a few chiral trialkylphosphines are available. Asymmetric catalytic performance is determined not only by the metal center but also by the chiral ligand selected.Synthetic Route of C33H25OP
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis