The total synthesis of (-)-strempeliopine via palladium-catalyzed decarboxylative asymmetric allylic alkylation was written by An, Yi;Wu, Mengjuan;Li, Weijian;Li, Yaling;Wang, Zhenzhen;Xue, Yansong;Tang, Pei;Chen, Fener. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Electric Literature of C28H23F9NOP This article mentions the following:
In the work reported herein, the concise and enantioselective total synthesis of the Schizozygine alkaloid (-)-strempeliopine was developed. This synthetic strategy featured the palladium-catalyzed decarboxylative asym. allylic alkylation of N-benzoyl lactam to set up the absolute configuration at the C20 position, a highly diastereoselective one-pot Bischler-Napieralski/lactamization and iminium reduction sequence for the construction of the pentacyclic core structure, and the late-stage dearomative addition of indole, leading to the otherwise difficult-to-achieve hexacyclic indoline framework with complete control of four neighboring stereocenters. In the experiment, the researchers used many compounds, for example, (R)-2-(2-(Bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole (cas: 1006708-91-3Electric Literature of C28H23F9NOP).
(R)-2-(2-(Bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole (cas: 1006708-91-3) belongs to chiral phosphine ligands. Many phosphine-catalyzed reactions have been developed for the syntheses of various biologically important acyclic and cyclic molecules. Asymmetric variants of these reactions have evolved relatively slowly. Over the last decade, however, and especially since 2005, considerable progress has been made in asymmetric phosphine catalysis.Electric Literature of C28H23F9NOP
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis