Asymmetric Friedel-crafts reaction of indole and cyclic enamine was written by Zhou, Jian-qing;Xu, Kai;Wang, Dan-jie;Cai, Zheng-yi;Gao, Jian-rong;Jia, Yi-xia. And the article was included in Zhejiang Huagong in 2013.Related Products of 1043567-32-3 This article mentions the following:
Friedel-Crafts alkylation reaction of 3-methylene-isoindol-1-one and indole catalyzed by chiral phosphoric acid was studied. With the optimization of catalyst, solvent and reaction temperature, the optimum catalyst was (S)-1-naphthyl replaced CPA-5 chiral phosphoric acid, optimum solvent was dichloromethane. The reaction could obtain 51% stereoselectivity under the room temperature Under these conditions, the substituent effect of indole was investigated, good reaction yield and 39%∼64% ee were obtained. In the experiment, the researchers used many compounds, for example, (11bS)-4-Hydroxy-2,6-di(phenanthren-9-yl)dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide (cas: 1043567-32-3Related Products of 1043567-32-3).
(11bS)-4-Hydroxy-2,6-di(phenanthren-9-yl)dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide (cas: 1043567-32-3) belongs to chiral phosphine ligands. Thousands of arylphosphines have been used as chiral ligands for metal-catalyzed asymmetric reactions. Chiral phosphine catalysts: Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates.Related Products of 1043567-32-3
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis