Enantioselective Dearomative Arylation of Isoquinolines was written by Zhang, Ming;Sun, Wangsheng;Zhu, Gongming;Bao, Guangjun;Zhang, Bangzhi;Hong, Liang;Li, Min;Wang, Rui. And the article was included in ACS Catalysis in 2016.Reference of 1043567-32-3 This article mentions the following:
The C1-substituted tetrahydroisoquinolines and 1,2-dihydroisoquinoline constitute an important group and are interesting structural motifs found in many natural products and pharmaceuticals. In this context, a phosphoric acid-catalyzed enantioselective dearomative arylation of isoquinolines was realized, providing the chiral dihydroisoquinolines with indole substituents at the C1-position in good results (up to >99% yield and 97% ee). The reaction features mild reaction conditions and operational simplicity, which make it an attractive approach to the discovery of biol. interesting α-indolisoquinolines. In the experiment, the researchers used many compounds, for example, (11bS)-4-Hydroxy-2,6-di(phenanthren-9-yl)dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide (cas: 1043567-32-3Reference of 1043567-32-3).
(11bS)-4-Hydroxy-2,6-di(phenanthren-9-yl)dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide (cas: 1043567-32-3) belongs to chiral phosphine ligands. During the past two decades, tertiary phosphine catalysts have been applied extensively in a wide range of carbon–carbon and carbon–heteroatom bond-forming transformations. Asymmetric catalytic performance is determined not only by the metal center but also by the chiral ligand selected.Reference of 1043567-32-3
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis