Organocatalytic Enantioselective Construction of Axially Chiral Tetrasubstituted Allenes via 1,6-Addition of Alkynyl Indole Imine Methides with 2-Substituted Indoles was written by Wu, Yu;Yue, Zhibin;Qian, Chenxiao;Chen, Xuling;Li, Fushuai;Li, Pengfei;Li, Wenjun. And the article was included in Asian Journal of Organic Chemistry in 2022.HPLC of Formula: 1043567-32-3 This article mentions the following:
An organocatalytic construction of axially chiral tetrasubstituted allenes I [R1 = H, 5-F, 6-OMe, etc.; R2 = H, F, Cl, Br; R3 = Me, t-Bu, Ph, etc.; R4 = Et, i-Pr, t-Bu, Bn; Ar1 = Ph, 4-FC6H4, 3-FC6H4, 3-MeC6H4] featuring indole skeletons was established. With the aid of chiral phosphoric acid, alkynyl indole imine methides were formed in situ from α-(3-indolyl) propargylic alcs., followed by the asym. 1,6-conjugate addition with 2-substituted indoles, furnishing axially chiral indole-containing tetrasubstituted allenes in generally high yields and enantioselectivities. In the experiment, the researchers used many compounds, for example, (11bS)-4-Hydroxy-2,6-di(phenanthren-9-yl)dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide (cas: 1043567-32-3HPLC of Formula: 1043567-32-3).
(11bS)-4-Hydroxy-2,6-di(phenanthren-9-yl)dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide (cas: 1043567-32-3) belongs to chiral phosphine ligands. Many phosphine-catalyzed reactions have been developed for the syntheses of various biologically important acyclic and cyclic molecules. Asymmetric variants of these reactions have evolved relatively slowly. Asymmetric catalytic performance is determined not only by the metal center but also by the chiral ligand selected.HPLC of Formula: 1043567-32-3
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis