Palladium-catalyzed asymmetric [3 + 3] cycloaddition of trimethylenemethane derivatives with nitrones was written by Shintani, Ryo;Park, Soyoung;Duan, Wei-Liang;Hayashi, Tamio. And the article was included in Angewandte Chemie, International Edition in 2007.Recommanded Product: (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine This article mentions the following:
Functionalized 1,2-oxazines can be obtained in high yield by a palladium-catalyzed asym. [3 + 3] cycloaddition of trimethylenemethane derivatives with nitrones. The use of a modified phosphoramidite ligand has led to the formation of these compounds with high stereoselectivity (see scheme, Cp = cyclopentadienyl). In the experiment, the researchers used many compounds, for example, (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3Recommanded Product: (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine).
(11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3) belongs to chiral phosphine ligands. Generally, the efficiency of nucleophilic phosphine catalysis often depends on the nature of the tertiary phosphine. Chiral ligands coordinate to metal centers to create an asymmetric environment around the reaction centers, which eventually affects enantioselectivity and reaction rate.Recommanded Product: (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis