Highly Efficient Rhodium/Monodentate Phosphoramidite Catalyst and Its Application in the Enantioselective Hydrogenation of Enamides and α-Dehydroamino Acid Derivatives was written by Jia, Xian;Li, Xingshu;Xu, Lijin;Shi, Qian;Yao, Xinsheng;Chan, Albert S. C.. And the article was included in Journal of Organic Chemistry in 2003.HPLC of Formula: 252288-04-3 This article mentions the following:
An easily prepared and highly efficient monodentate phosphoramidite ligand (S)-2,2′-O,O-(1,1′-binaphthyl)-dioxo-N,N-diethylphospholidine, derived from BINOL, was examined in the hydrogenation of both enamides H2C:CR1NHCOMe (R1 = Ph, 4-F3CC6H4, 3-MeOC6H4, 1-naphthyl, etc.) and α-dehydroamino acid esters R2CH:C(NHR3)CO2Me (R2 = H, Ph, 4-FC6H4, 4-MeOC6H4, etc.; R3 = MeCO, PhCO). The catalyst provided remarkably high enantioselectivities (up to 99.6% ee for enamides and >99.9% ee for α-dehydroamino acid esters). In the experiment, the researchers used many compounds, for example, (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3HPLC of Formula: 252288-04-3).
(11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3) belongs to chiral phosphine ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge. Effective chiral catalysts for nucleophilic phosphine catalysis are scarce, seriously limiting the development of asymmetric variants. HPLC of Formula: 252288-04-3
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis