Yang, Xiangbo published the artcileDiscovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders, Product Details of C9H20Cl2N2O, the publication is European Journal of Medicinal Chemistry (2021), 113341, database is CAplus and MEDLINE.
Design, synthesis and evaluation of a series of thalidomide-based heterobifunctional mols. and identified compound I as highly efficient SHP2 degrader with a DC50 of 6.02 nM was described. Further mechanism investigation illustrated that compound I came into function through targeted SHP2 protein degradation
European Journal of Medicinal Chemistry published new progress about 2055761-19-6. 2055761-19-6 belongs to chiral-phosphine-ligands, auxiliary class Spiro[4.5], name is (3S,4S)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine dihydrochloride, and the molecular formula is C16H24BF4Ir, Product Details of C9H20Cl2N2O.
Referemce:
https://en.wikipedia.org/wiki/Phosphine_ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate