Xu, Qi published the artcileCu(I)-Catalyzed Asymmetric Arylation of Pyrroles with Diaryliodonium Salts toward the Synthesis of N-N Atropisomers, Formula: C40H36O4P2, the publication is Organic Letters (2022), 24(17), 3138-3143, database is CAplus and MEDLINE.
The copper(I) catalysis using a bis(phosphine) dioxide ligand could catalyze the desym. C-H arylation of prochiral bipyrroles was reported. More than 50 nitrogen-nitrogen atropisomers I [R1 = Ph, 3-ClC6H4, 2-naphthyl, etc.; R2 = Me, Et, Bn, etc.; R3 = Me, Et, i-Pr; R4 = H, Me; R1R4 = CH=CH-CH=CH; Ar = Ph, 4-MeC6H4, 3-ClC6H4, etc.] were achieved in good to excellent yields with excellent enantioselectivities (≤97% yield, ≤98% ee). The reaction proceeded under mild conditions with good functional group compatibility on arenes and diaryliodonium salts. Moreover, this principle enabled iterative arylation of the bipyrroles to enantioselectively arylate different positions during the catalysis of copper.
Organic Letters published new progress about 1365531-76-5. 1365531-76-5 belongs to chiral-phosphine-ligands, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (S)-2,2′-Bis(diphenylphosphino)-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl, and the molecular formula is C11H14O2, Formula: C40H36O4P2.
Referemce:
https://en.wikipedia.org/wiki/Phosphine_ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate