Wang, Cheng-Jie published the artcileCatalytic asymmetric 1,4-type Friedel-Crafts (hetero)arylations of 1-azadienes: the highly enantioselective syntheses of chiral hetero-triarylmethanes, Recommanded Product: R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate, the publication is Organic Chemistry Frontiers (2020), 7(3), 609-616, database is CAplus.
Direct enantioselective Michael-type Friedel-Crafts arylations and heteroarylations of s-cis 1-azadienes I (R = H, Me; R1 = Ph, thiophen-2-yl, 4-chlorophenyl, etc.) were achieved by applying chiral bifunctional tertiary amine-urea catalysts when using 2-naphthols II (R2 = H, 6-(naphthalen-1-yl), 7-methoxy, 6-bromo) as the nucleophiles, and phosphoric acid catalysts when using indoles III (R3 = H, Me; R4 = H, Me, Ph; R5 = H, OMe, Br) as the nucleophiles. These two catalytic protocols efficiently enabled access to a diverse variety of important benzofuran-containing hetero-triarylmethanes IV and V in up to 98% yield and with 99.5 : 0.5 er.
Organic Chemistry Frontiers published new progress about 929294-27-9. 929294-27-9 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate, and the molecular formula is C3H5BN2O2, Recommanded Product: R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate.
Referemce:
https://en.wikipedia.org/wiki/Phosphine_ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate