Month: November 2022

Lorraine, Shannen’s team published research in Inorganica Chimica Acta in 511 | CAS: 1365531-76-5

Inorganica Chimica Acta published new progress about 1365531-76-5. 1365531-76-5 belongs to chiral-phosphine-ligands, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (S)-2,2′-Bis(diphenylphosphino)-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl, and the molecular formula is C40H36O4P2, Quality Control of 1365531-76-5.

Lorraine, Shannen published the artcileBiaryl diphosphine ligands and their ruthenium complexes: Preparation and use for catalytic hydrogenation of ketones, Quality Control of 1365531-76-5, the publication is Inorganica Chimica Acta (2020), 119850, database is CAplus.

Procedures for the preparation of the nucleophilic diphosphine ligands (R)-(4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl)bis(diphenylphosphine) ((R)-Ph-Garphos) and (S)-(4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl)bis(diphenylphosphine) ((S)-Ph-Garphos) were described. The ligands were used to prepare the ruthenium(II) Ph-Garphos complexes, chloro(p-cymene)(R)-(4,4′,6,6′-tetraamethoxybiphenyl-2,2′-diyl)bis(diphenylphosphine)ruthenium(II) chloride ([RuCl(p-cymene)(R)-Ph-Garphos]Cl (3)) and chloro(p-cymene)(S)-(4,4′,6,6′-tetraamethoxybiphenyl-2,2′-diyl)bis(diphenylphosphine)ruthenium(II) chloride ([RuCl(p-cymene)(S)-Ph-Garphos]Cl (4)). In the presence of the chiral diamine co-ligands (1R,2R)-1,2-diphenylethane-1,2-diamine (R,R-DPEN) and (1S,2S)-1,2-diphenylethane-1,2-diamine (S,S-DPEN), complexes 3 and 4 were found to be catalyst precursors for the enantioselective reduction of aryl ketones under mild conditions (room temperature and 3-4 atm of H2). The chiral alcs. were isolated in moderate to good yields and with enantioselectivities of up to 93%. The ruthenium complexes chloro(p-cymene)(R)-(4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-dimethylphenyl)-phosphine)ruthenium(II) chloride ([RuCl(p-cymene)(R)-Xyl-Garphos]Cl (5)) and chloro(p-cymene)(S)-(4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-dimethylphenyl)-phosphine)ruthenium(II) chloride ([RuCl(p-cymene)(S)-Xyl-Garphos]Cl (6)) were also prepared and used as catalyst precursors for the hydrogenation of aryl ketones in the presence of (R,R)-DPEN and (S,S)-DPEN. Significant improvements in the enantioselectivities of the alcs. (up to 98% ee.) were afforded. A combination of 6 and (S,S)-DPEN afforded (R)-1-(3-methoxyphenyl)ethanol in 89% yield and with 95% ee which was shown to be a suitable precursor for the preparation of (S)-rivastigmine.

Inorganica Chimica Acta published new progress about 1365531-76-5. 1365531-76-5 belongs to chiral-phosphine-ligands, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (S)-2,2′-Bis(diphenylphosphino)-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl, and the molecular formula is C40H36O4P2, Quality Control of 1365531-76-5.

Referemce:
https://en.wikipedia.org/wiki/Phosphine_ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Pan, Subhas Chandra’s team published research in Angewandte Chemie, International Edition in 46 | CAS: 929294-27-9

Angewandte Chemie, International Edition published new progress about 929294-27-9. 929294-27-9 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate, and the molecular formula is C50H65O4P, Safety of R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate.

Pan, Subhas Chandra published the artcileCatalytic asymmetric acylcyanation of imines. [Erratum to document cited in CA146:337461], Safety of R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate, the publication is Angewandte Chemie, International Edition (2007), 46(17), 2971, database is CAplus.

On page 614, reference [11c], citation of a parallel report discussing a non-enantioselective variant of the presented reaction was omitted. Reference [11c] should read: “c) for a non-enantioselective thiourea-catalyzed variant, see: S. C. Pan, J. Zhou, B. List, Synlett 2006, 3275-3276.”.

Angewandte Chemie, International Edition published new progress about 929294-27-9. 929294-27-9 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate, and the molecular formula is C50H65O4P, Safety of R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate.

Referemce:
https://en.wikipedia.org/wiki/Phosphine_ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Pan, Subhas Chandra’s team published research in Angewandte Chemie, International Edition in 46 | CAS: 929294-27-9

Angewandte Chemie, International Edition published new progress about 929294-27-9. 929294-27-9 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate, and the molecular formula is C50H65O4P, Application In Synthesis of 929294-27-9.

Pan, Subhas Chandra published the artcileCatalytic asymmetric acylcyanation of imines, Application In Synthesis of 929294-27-9, the publication is Angewandte Chemie, International Edition (2007), 46(4), 612-614, database is CAplus and MEDLINE.

The less problematic acetyl cyanide was used instead of toxic HCN for the highly enantioselective acyl-Strecker-type reaction. In the presence of an N-benzylimine and a catalytic amount of chiral phosphoric acids or thioureas, the desired amidonitriles were obtained in excellent enantioselectivities and yields.

Angewandte Chemie, International Edition published new progress about 929294-27-9. 929294-27-9 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate, and the molecular formula is C50H65O4P, Application In Synthesis of 929294-27-9.

Referemce:
https://en.wikipedia.org/wiki/Phosphine_ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Bai, Jian-Fei’s team published research in Organic Letters in 22 | CAS: 929294-27-9

Organic Letters published new progress about 929294-27-9. 929294-27-9 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate, and the molecular formula is C50H65O4P, Product Details of C50H65O4P.

Bai, Jian-Fei published the artcileOrganocatalytic Formal (3+2) Cycloaddition toward Chiral Pyrrolo[1,2-a]indoles via Dynamic Kinetic Resolution of Allene Intermediates, Product Details of C50H65O4P, the publication is Organic Letters (2020), 22(14), 5439-5445, database is CAplus and MEDLINE.

The chiral phosphoric acid catalyzed formal (3+2) cycloaddition of 3-substituted 1H-indoles and propargylic alcs. containing a functional directing group (p-NHAc or p-OH) was reported. A straightforward method to synthesize chiral pyrrolo[1,2-a]indole bearing a tetrasubstituted carbon stereocenter was represented. The reaction proceeded smoothly with a wide array of substrate tolerance to deliver various chiral pyrrolo[1,2-a]indoles in up to 93% yield and 98% ee. The utility of this method is highlighted by the diverse transformations of the products into various indole derivatives

Organic Letters published new progress about 929294-27-9. 929294-27-9 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate, and the molecular formula is C50H65O4P, Product Details of C50H65O4P.

Referemce:
https://en.wikipedia.org/wiki/Phosphine_ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Wang, Dongqiang’s team published research in Journal of Separation Science in 38 | CAS: 297752-25-1

Journal of Separation Science published new progress about 297752-25-1. 297752-25-1 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is (R)-4-Hydroxy-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide, and the molecular formula is C9H11BO4, Quality Control of 297752-25-1.

Wang, Dongqiang published the artcilePreparation and evaluation of novel chiral stationary phases based on quinine derivatives comprising crown ether moieties, Quality Control of 297752-25-1, the publication is Journal of Separation Science (2015), 38(2), 205-210, database is CAplus and MEDLINE.

The C9-position of quinine was modified by meta- or para-substituted benzo-18-crown-6, and immobilized on 3-mercaptopropyl-modified silica gel through the radical thiol-ene addition reaction. These two chiral stationary phases were evaluated by chiral acids, amino acids, and chiral primary amines. The crown ether moiety on the quinine anion exchanger provided a ligand-exchange site for primary amino groups, which played an important role in the retention and enantioselectivity for chiral compounds containing primary amine groups. These two stationary phases showed good selectivity for some amino acids. The complex interaction between crown ether and protonated primary amino group was studied by the addition of inorganic salts such as LiCl, NH4Cl, NaCl, and KCl to the mobile phase. The resolution results showed that the simultaneous interactions between two function moieties (quinine and crown ether) and amino acids were important for the chiral separation

Journal of Separation Science published new progress about 297752-25-1. 297752-25-1 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is (R)-4-Hydroxy-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide, and the molecular formula is C9H11BO4, Quality Control of 297752-25-1.

Referemce:
https://en.wikipedia.org/wiki/Phosphine_ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Xu, Qi’s team published research in Organic Letters in 24 | CAS: 1365531-76-5

Organic Letters published new progress about 1365531-76-5. 1365531-76-5 belongs to chiral-phosphine-ligands, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (S)-2,2′-Bis(diphenylphosphino)-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl, and the molecular formula is C11H14O2, Formula: C40H36O4P2.

Xu, Qi published the artcileCu(I)-Catalyzed Asymmetric Arylation of Pyrroles with Diaryliodonium Salts toward the Synthesis of N-N Atropisomers, Formula: C40H36O4P2, the publication is Organic Letters (2022), 24(17), 3138-3143, database is CAplus and MEDLINE.

The copper(I) catalysis using a bis(phosphine) dioxide ligand could catalyze the desym. C-H arylation of prochiral bipyrroles was reported. More than 50 nitrogen-nitrogen atropisomers I [R1 = Ph, 3-ClC6H4, 2-naphthyl, etc.; R2 = Me, Et, Bn, etc.; R3 = Me, Et, i-Pr; R4 = H, Me; R1R4 = CH=CH-CH=CH; Ar = Ph, 4-MeC6H4, 3-ClC6H4, etc.] were achieved in good to excellent yields with excellent enantioselectivities (≤97% yield, ≤98% ee). The reaction proceeded under mild conditions with good functional group compatibility on arenes and diaryliodonium salts. Moreover, this principle enabled iterative arylation of the bipyrroles to enantioselectively arylate different positions during the catalysis of copper.

Organic Letters published new progress about 1365531-76-5. 1365531-76-5 belongs to chiral-phosphine-ligands, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (S)-2,2′-Bis(diphenylphosphino)-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl, and the molecular formula is C11H14O2, Formula: C40H36O4P2.

Referemce:
https://en.wikipedia.org/wiki/Phosphine_ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Wang, Cheng-Jie’s team published research in Organic Chemistry Frontiers in 7 | CAS: 929294-27-9

Organic Chemistry Frontiers published new progress about 929294-27-9. 929294-27-9 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate, and the molecular formula is C3H5BN2O2, Recommanded Product: R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate.

Wang, Cheng-Jie published the artcileCatalytic asymmetric 1,4-type Friedel-Crafts (hetero)arylations of 1-azadienes: the highly enantioselective syntheses of chiral hetero-triarylmethanes, Recommanded Product: R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate, the publication is Organic Chemistry Frontiers (2020), 7(3), 609-616, database is CAplus.

Direct enantioselective Michael-type Friedel-Crafts arylations and heteroarylations of s-cis 1-azadienes I (R = H, Me; R1 = Ph, thiophen-2-yl, 4-chlorophenyl, etc.) were achieved by applying chiral bifunctional tertiary amine-urea catalysts when using 2-naphthols II (R2 = H, 6-(naphthalen-1-yl), 7-methoxy, 6-bromo) as the nucleophiles, and phosphoric acid catalysts when using indoles III (R3 = H, Me; R4 = H, Me, Ph; R5 = H, OMe, Br) as the nucleophiles. These two catalytic protocols efficiently enabled access to a diverse variety of important benzofuran-containing hetero-triarylmethanes IV and V in up to 98% yield and with 99.5 : 0.5 er.

Organic Chemistry Frontiers published new progress about 929294-27-9. 929294-27-9 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate, and the molecular formula is C3H5BN2O2, Recommanded Product: R-3,3′-Bis(2,4,6-triisopropylphenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate.

Referemce:
https://en.wikipedia.org/wiki/Phosphine_ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Yang, Chen’s team published research in Journal of Organic Chemistry in 78 | CAS: 297752-25-1

Journal of Organic Chemistry published new progress about 297752-25-1. 297752-25-1 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is (R)-4-Hydroxy-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide, and the molecular formula is C4H5F3N2O3S, Recommanded Product: (R)-4-Hydroxy-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide.

Yang, Chen published the artcileTheoretical Study on the Acidities of Chiral Phosphoric Acids in Dimethyl Sulfoxide: Hints for Organocatalysis, Recommanded Product: (R)-4-Hydroxy-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide, the publication is Journal of Organic Chemistry (2013), 78(14), 7076-7085, database is CAplus and MEDLINE.

The pKa values of 41 chiral phosphoric acid-family catalysts in DMSO were predicted using the SMD/M06-2x/6-311++G(2df,2p)//B3LYP/6-31+G(d) method for the first time. The study showed that the calculated pKa‘s range from -4.23 to 6.16 for absolute pKa values and from -4.21 to 6.38 for relative pKa values. Excellent agreement between the calculated and exptl. pKa‘s was achieved for the few available cases (to a precision of around 0.4 pKa unit), indicating that this strategy may be suitable for calculating highly accurate pKa‘s. A good linear correlation between the pKa‘s for 3 and 3’ disubstituted Ph BINOL phosphoric acids and the Hammett constants was obtained. The relationship between the acidities of phosphoric acid catalysts and their reaction activity and selectivity was also discussed. Knowledge of the pKa values of phosphoric acids should be of great value for the understanding of chiral Bronsted acid-catalyzed reactions and may aid in future catalyst design.

Journal of Organic Chemistry published new progress about 297752-25-1. 297752-25-1 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is (R)-4-Hydroxy-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide, and the molecular formula is C4H5F3N2O3S, Recommanded Product: (R)-4-Hydroxy-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide.

Referemce:
https://en.wikipedia.org/wiki/Phosphine_ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Zhao, Jianchao’s team published research in Journal of Separation Science in 38 | CAS: 297752-25-1

Journal of Separation Science published new progress about 297752-25-1. 297752-25-1 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is (R)-4-Hydroxy-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide, and the molecular formula is C14H14N2O2, Recommanded Product: (R)-4-Hydroxy-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide.

Zhao, Jianchao published the artcileImprovement of chiral stationary phases based on cinchona alkaloids bonded to crown ethers by chiral modification, Recommanded Product: (R)-4-Hydroxy-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide, the publication is Journal of Separation Science (2015), 38(22), 3884-3890, database is CAplus and MEDLINE.

To improve the chiral recognition capability of a cinchona alkaloid crown ether chiral stationary phase, the crown ether moiety was modified by the chiral group of (1S,2S)-2-aminocyclohexyl phenylcarbamate. Both quinine and quinidine-based stationary phases were evaluated by chiral acids, chiral primary amines and amino acids. The quinine/quinidine and crown ether provided ion-exchange sites and complex interaction site for carboxyl group and primary amine group in amino acids, resp., which were necessary for the chiral discrimination of amino acid enantiomers. The introduction of the chiral group greatly improved the chiral recognition for chiral primary amines. The structure of crown ether moiety was proved to play a dominant role in the chiral recognitions for chiral primary amines and amino acids.

Journal of Separation Science published new progress about 297752-25-1. 297752-25-1 belongs to chiral-phosphine-ligands, auxiliary class Chiral Phosphoric Acids, name is (R)-4-Hydroxy-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide, and the molecular formula is C14H14N2O2, Recommanded Product: (R)-4-Hydroxy-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide.

Referemce:
https://en.wikipedia.org/wiki/Phosphine_ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Yang, Xiangbo’s team published research in European Journal of Medicinal Chemistry in 218 | CAS: 2055761-19-6

European Journal of Medicinal Chemistry published new progress about 2055761-19-6. 2055761-19-6 belongs to chiral-phosphine-ligands, auxiliary class Spiro[4.5], name is (3S,4S)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine dihydrochloride, and the molecular formula is C16H24BF4Ir, Product Details of C9H20Cl2N2O.

Yang, Xiangbo published the artcileDiscovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders, Product Details of C9H20Cl2N2O, the publication is European Journal of Medicinal Chemistry (2021), 113341, database is CAplus and MEDLINE.

Design, synthesis and evaluation of a series of thalidomide-based heterobifunctional mols. and identified compound I as highly efficient SHP2 degrader with a DC50 of 6.02 nM was described. Further mechanism investigation illustrated that compound I came into function through targeted SHP2 protein degradation

European Journal of Medicinal Chemistry published new progress about 2055761-19-6. 2055761-19-6 belongs to chiral-phosphine-ligands, auxiliary class Spiro[4.5], name is (3S,4S)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine dihydrochloride, and the molecular formula is C16H24BF4Ir, Product Details of C9H20Cl2N2O.

Referemce:
https://en.wikipedia.org/wiki/Phosphine_ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate