Month: October 2022

Bandini, Marco; Gualandi, Andrea; Monari, Magda; Romaniello, Alessandro; Savoia, Diego; Tragni, Michele published the artcile< Allylic alcohols: Valuable synthetic equivalents of non-activated alkenes in gold-catalyzed enantioselective alkylation of indoles>, Recommanded Product: (S)-(+)-4,12-Bis(di(3,5-xylyl)phosphino)-[2.2]-paracyclophane, the main research area is allylic alc tethered indole derivative preparation; chiral ligand gold catalyzed intramol allylic alkylation indole derivative; tetrahydrocarbazole derivative stereoselective preparation; tetrahydrocarboline derivative stereoselective preparation.

The recent booming of gold catalysis has demonstrated that unprecedented transformations can be realized in a highly selective manner. Moreover, due to the growing availability of chiral organic ligands, gold-catalysis can be considered as one of most dynamic hot spots in asym. synthesis. However, in this context, the use of non-activated olefinic C-C double bonds is still largely unexplored due to the intrinsic inertness of C=C (respect to allenes and alkynes) in taking part in nucleophilic additions assisted by π-electrophilic activations. Allylic alcs. have been demonstrated to be feasible “”surrogates”” of non-activated alkenes for the enantioselective allylic alkylation of indoles catalyzed by chiral gold(I) complexes. In this investigation, a full account addressing efficiency and substrate scope of such a process is presented. The products, tetrahydrocarbazoles or tetrahydro-β-carbolines, are obtained in moderate to good yields and 40-86% ee from the corresponding Z-allylic alc.-containing substrates, while the E isomers are unreactive.

Journal of Organometallic Chemistrypublished new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 325168-88-5 belongs to class chiral-phosphine-ligands, and the molecular formula is C48H50P2, Recommanded Product: (S)-(+)-4,12-Bis(di(3,5-xylyl)phosphino)-[2.2]-paracyclophane.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Driver, Tom G.; Harris, Jason R.; Woerpel, K. A. published the artcile< Kinetic Resolution of Hydroperoxides with Enantiopure Phosphines: Preparation of Enantioenriched Tertiary Hydroperoxides>, Product Details of C48H50P2, the main research area is hydroperoxide tertiary reductive kinetic resolution cyclophane phosphine.

An efficient reductive kinetic resolution strategy capable of accessing optically active tertiary hydroperoxides R1R2C(Ph)OOH (R1 = H, Me; R2 = Et, n-Pr, Me2CH, cyclohexyl, Me3CSiMe2OCH2, etc.) is reported. Readily accessible tertiary hydroperoxides are resolved with com. available (R)- or (S)-xylyl-PHANEPHOS with selectivity factors as large as 37. The resulting bis(phosphine oxide) can be recycled in high yields. The isolated mono(phosphine oxide) intermediate resolved hydroperoxides with the same selectivity as the parent bis-phosphine.

Journal of the American Chemical Societypublished new progress about Hydroperoxides Role: PUR (Purification or Recovery), RCT (Reactant), SPN (Synthetic Preparation), PREP (Preparation), RACT (Reactant or Reagent). 325168-88-5 belongs to class chiral-phosphine-ligands, and the molecular formula is C48H50P2, Product Details of C48H50P2.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Trost, Barry M.; Xu, Jiayi; Schmidt, Thomas published the artcile< Ligand Controlled Highly Regio- and Enantioselective Synthesis of α-Acyloxyketones by Palladium-Catalyzed Allylic Alkylation of 1,2-Enediol Carbonates>, Application In Synthesis of 152140-65-3, the main research area is enediol carbonate allyl alkylation palladium catalysis ligand; acetoxyketone asym preparation.

The palladium-catalyzed decarboxylative asym. allylic alkylation of allyl 1,2-enediol carbonates can decompose to either α-hydroxyketones or α-hydroxyaldehydes. The product distribution is largely controlled by the ligand. Using Lnaph in DME the ketone product is obtained in good to excellent yields and high enantiomeric excesses. The reaction proceeds under extremely mild conditions and was tested with a broad range of ester substrates. Besides commonly used protection groups, such as OAc and OPiv, a more functionalized group, Me but-2-enoyl, is also used that can eventually afford other synthetically interesting structures.

Journal of the American Chemical Societypublished new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, Application In Synthesis of 152140-65-3.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate