Trost, Barry M.; Lehr, Konrad; Michaelis, David J.; Xu, Jiayi; Buckl, Andreas K. published the artcile< Palladium-Catalyzed Asymmetric Allylic Alkylation of 2-Acylimidazoles as Ester Enolate Equivalents>, HPLC of Formula: 152140-65-3, the main research area is cetiedil stereoselective preparation; acylimidazole stereoselective preparation; imidazolyl allyl enol carbonate enantioselective allylic alkylation palladium catalyst; unsaturated carbonyl compound preparation acylimidazole hydrolysis.
A broad range of highly enantioenriched 2-acylimidazoles, e.g. I, are synthesized by palladium-catalyzed decarboxylative asym. allylic alkylation (DAAA) of 2-imidazolo-substituted enol carbonates, e.g. II. The enantioenriched 2-acylimidazole products can easily be converted to the corresponding carboxylic acid (e.g. III), ester, amide, and ketone derivatives with complete retention of the enantiopurity. The synthetic utility of this new method is demonstrated in the short, efficient synthesis of cetiedil IV.
Journal of the American Chemical Society published new progress about Allylic alkylation catalysts. 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, HPLC of Formula: 152140-65-3.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate