Application of 286454-86-2On May 26, 2016, Chen, Peng; Su, Xiao; Zhou, Wei; Xiao, Yuanjing; Zhang, Junliang published an article in Tetrahedron. The article was 《Novel chiral sulfinamide phosphines: valuable precursors to chiral β-aminophosphines》. The article mentions the following:
Starting from com. available aldehyde and chiral tert-butanesulfinamide, chiral sulfinamide phosphines Ph2PCH2CH(R)NHS(:O)But (Xiao-Phos, R = alkyl, aryl, hetaryl) were synthesized via a two-step condensation-nucleophilic addition procedure. In most cases, nucleophilic addition of the N-tert-butanesulfinyl imine with [(diphenylphosphino)methyl]lithium (Ph2PCH2Li) showed high diastereoselectivity (d.r > 20:1) with BF3 as additives. Following removal of the chiral auxiliary, an important class of ligands i.e. chiral β-aminophosphines and its derivatives were obtained in high yields using this approach. The experimental part of the paper was very detailed, including the reaction process of (S)-1-(Diphenylphosphino)-3,3-dimethylbutan-2-amine(cas: 286454-86-2Application of 286454-86-2)
(S)-1-(Diphenylphosphino)-3,3-dimethylbutan-2-amine(cas:286454-86-2) is one of aminophosphine type ligands. An increased interest in aminophosphine type ligands used for asymmetric synthesis has been witnessed.Application of 286454-86-2 This growth in popularity of aminophosphine ligands in asymmetric synthesis is in part due to the growing number of convenient synthetic pathways leading to useful ligand sets.
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis