In 2019,Organic Letters included an article by Quintard, Adrien; Rodriguez, Jean. Category: chiral-phosphine-ligands. The article was titled 《Enantioselective Ir-Catalyzed Bidirectional Reductive Coupling》. The information in the text is summarized as follows:
In the presence of a chiral iridium complex, com. available 3-chloro-2-chloromethyl-1-propene (1) was selectively activated for various reductive couplings. Depending on the reaction conditions it allows a selective mono- or bidirectional condensation with one or two external aldehydes with excellent enantiocontrol (>90% ee). This approach occurring simply under mild conditions and avoiding premetalated reagents constructs rapidly chiral homoallylic alcs., key precursors of important mol. fragments such as furans, pyrans, ketodiols, or 1,3,5-polyols. The results came from multiple reactions, including the reaction of (S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3Category: chiral-phosphine-ligands)
(S)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole(cas: 210169-54-3) may be used for: regio- and stereoselective preparation of axially chiral arylnaphthalene derivatives via rhodium-catalyzed [2+2+2] cycloaddition of diynes with naphthalenepropynoic acid derivatives or diastereo- and enantioselective hydrogenation of α-amino-β-keto ester hydrochlorides catalyzed by an iridium complex.Category: chiral-phosphine-ligands
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis