Related Products of 256390-47-3On March 31, 2011, Khan, Hasan A.; Kou, Kevin G. M.; Dong, Vy M. published an article in Chemical Science. The article was 《Nitrogen-directed ketone hydroacylation: Enantioselective synthesis of benzoxazecinones》. The article mentions the following:
A method for a nitrogen-directed ketone hydroacylation is reported to furnish eight-membered nitrogen-containing lactone (benzoxazecinone) derivatives in high yield and high enantiomeric excess. In a model study, a comparison was made between nitrogen, oxygen and sulfur directing groups and it was found that nitrogen promoted faster hydroacylation. By this catalytic transformation the synthesis of the target compounds (i.e., nitrogen heterocyclic compounds, benzoxazepinone derivatives and benzoxazecinone derivatives) was achieved and it was discovered that, moreover, an amine-directing group completely suppressed a competitive decarbonylation reaction. The experimental part of the paper was very detailed, including the reaction process of (R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,4,5-trimethoxyphenyl)phosphine](cas: 256390-47-3Related Products of 256390-47-3)
(R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,4,5-trimethoxyphenyl)phosphine](cas: 256390-47-3) belongs to chiral phosphine ligands. Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates. Related Products of 256390-47-3 These intermediates are formed through nucleophilic attack of the phosphine catalysts at electron-poor nuclei (normally carbon atoms) and then proceed through several steps to form new chemical bonds.
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis