Tanielyan, Setrak K.; Marin, Norman; Alvez, Gabriela; Augustine, Robert L. published the artcile< Two Efficient Enantioselective Syntheses of 2-Amino-1-phenylethanol>, HPLC of Formula: 325168-88-5, the main research area is aminophenylethanolstereoselective preparation.
Two enantioselective methods for the synthesis of 2-amino-1-phenylethanol have been developed. The first uses an enantioselective oxazaborolidine-catalyzed borane reduction of 2-chloroacetophenone (phenacyl chloride) to give the chiral chloro alc. in good yield with an ee in the 93-97% range. Reaction with dilute ammonium hydroxide produced the amino alc. in good yield with a high ee. The second approach involved the conversion of phenacyl chloride to the succinimidoacetophenone which was then hydrogenated using a chiral ruthenium complex in conjunction with a base and an optically active amine (Noyori procedure). This gave the optically active succinimido alc. in very good yield with an ee of 98%. Hydrolysis with dilute base produced the optically active amino alc. in very good yield and excellent enantioselectivity.
Organic Process Research & Development published new progress about 325168-88-5. 325168-88-5 belongs to class chiral-phosphine-ligands, and the molecular formula is C48H50P2, HPLC of Formula: 325168-88-5.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate