Lavernhe, Remi; Alexy, Eric J.; Zhang, Haiming; Stoltz, Brian M. published the artcile< Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Protected Benzoin-Derived Enol Carbonates>, SDS of cas: 152140-65-3, the main research area is benzoin preparation enantioselective; allyl enol carbonate preparation decarboxylative allylic alkylation palladium catalyst; allylic alkylation; asymmetric catalysis; benzoin; palladium catalysis.
The enantioselective palladium-catalyzed decarboxylative allylic alkylation of fully substituted α-hydroxy acyclic enol carbonates (Z)-RC(OCO2allyl)=C(OMOM)R (R = C6H5, 2-naphthyl, 2H-1,3-benzodioxol-5-yl, etc.) providing tetrasubstituted benzoin derivatives (S)-RC(O)C(OMOM)(CH2CH=CH2)R is reported. Investigation into the transformation revealed that preparation of the starting material as a single enolate isomer is crucial for optimal enantioselectivity. The obtained alkylation products contain multiple reactive sites that can be utilized toward the synthesis of stereochem. rich derivatives
Advanced Synthesis & Catalysis published new progress about Allylic alkylation catalysts, stereoselective (decarboxylative). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, SDS of cas: 152140-65-3.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate