Lautens, Mark; Fagnou, Keith; Taylor, Mark published the artcile< Rhodium-catalyzed asymmetric ring opening of oxabicyclic alkenes with phenols>, SDS of cas: 277306-29-3, the main research area is oxabicyclic alkene asym ring opening phenol; rhodium asym ring opening oxabicyclic alkene; stereoselective enantioselective aryloxydihydronaphthalenol preparation.
The scope of the rhodium-catalyzed asym. ring opening reaction of oxabenzonorbornadiene has been extended to include phenolic nucleophiles XC6H4OH (X = 4-F, 4-Cl, 4-Br, 4-I, 4-MeCO, 4-F3C, 4-Me, 4-NC, 2-Br, 3-Br). The enantioenriched, functionalized dihydronaphthalene products, e.g., aryloxydihydronaphthalenol I, are highly valuable intermediates for which no other practical methods of preparation are available. Using [Rh(CO)2Cl]2 as the rhodium source and ferrocene II as the diphosphine ligand allows the use of less reactive o-halophenols in the stereoselective ring opening reaction. The utility of these products has been demonstrated through their application in the synthesis of benzofuran polycyclic materials, e.g, III.
Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 277306-29-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C32H40FeP2, SDS of cas: 277306-29-3.
Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate