Huang, Yu-Hao; Wu, Yichen; Zhu, Zile; Zheng, Sujuan; Ye, Zihang; Peng, Qian; Wang, Peng published the artcile< Enantioselective Synthesis of Silicon-Stereogenic Monohydrosilanes by Rhodium-Catalyzed Intramolecular Hydrosilylation>, Product Details of C44H40P2, the main research area is enantioselective regioselective preparation stereogenic cyclic monohydrosilane oxasilacycle; rhodium catalyzed intramol hydrosilylation; mol structure calculation cyclic monohydrosilane oxasilacycle; asymmetric synthesis; dihydrosilanes; hydrosilylation; monohydrosilane; rhodium.
Enantiopure monohydrosilanes are versatile chiral reagents for alc. resolution and mechanistic investigation. Herein, authors have demonstrated the asym. synthesis of monohydrosilanes via an intramol. hydrosilylation strategy. This protocol is suitable for the synthesis of five- and six-membered cyclic monohydrosilanes, including a class of chiral oxasilacycles, with excellent diastereo-, regio-, and enantioselectivities. Notably, the catalyst loading could be reduced to 0.1 mol % which makes this one of the most efficient methods to access chiral monohydrosilanes. Mechanistic studies and DFT calculations indicate this Rh-catalyzed intramol. asym. hydrosilylation reaction might proceed via a Chalk-Harrod mechanism, and the enantio-determining step was predicted to be oxidative addition of Si-H bond.
Angewandte Chemie, International Edition published new progress about Crystal structure. 139139-93-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Product Details of C44H40P2.
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate